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The Type of Probiotic That May Reverse Depression

The probiotic buffered the body against the damaging effects of stress.

Depression has been reversed in mice by feeding them probiotic bacteria, new research reports.

Lactobacillus is a type of ‘good’ bacteria found in yogurt, among other foods.

The role of the gut microbiome — the bacteria which live in our gut — has become a focus of research interest recently.

Dr Alban Gaultier, who led the study, said:

“The big hope for this kind of research is that we won’t need to bother with complex drugs and side effects when we can just play with the microbiome.
It would be magical just to change your diet, to change the bacteria you take, and fix your health — and your mood.”

The scientists found that when mice in the study were put under stress, the bacteria in their gut changed.

The main change was a reduction in Lactobacillus, which was linked to depressed behaviour in the mice.

Feeding them Lactobacillus almost completely stopped their depressive behaviours.


The researchers found a mechanism for how this change in the gut led to depression (it is through a metabolite called kynurenine).

First author, Ms Ioana Marin said:

“This is the most consistent change we’ve seen across different experiments and different settings we call microbiome profiles.
This is a consistent change.
We see Lactobacillus levels correlate directly with the behavior of these mice.”

The researchers plan to continue investigating kynurenine’s role in depression, Ms Marin said:

“There has been some work in humans and quite a bit in animal models talking about how this metabolite, kynurenine, can influence behavior.
It’s something produced with inflammation that we know is connected with depression.
But the question still remains: How?
How does this molecule affect the brain?
What are the processes?
This is the road we want to take.”

The study was published in the journal Scientific Reports (Marin et al., 2017).
MARCH 15, 2017
source: PsyBlog


Boost Your Immune System And Ward Off Viruses With These Foods

Chicken soup helps, sure, but a diet rich in vegetables, fish and even garlic can help lessen the severity of a cold or prevent you from getting sick.

The combination of chicken, homemade broth, veggies (such as carrots, celery and onions) and noodles or rice in chicken soup is immune-boosting and soothing, and the warm broth clears your nasal passages and keeps you hydrated.

Winter doesn’t just bring the blues, it also gifts us with coughs, runny noses and sore throats. It’s not because of the old adage of bundling up or “you’ll catch a cold!” We tend to get more cold and flu viruses during the winter as germs survive longer indoors due to poor ventilation and lack of humidity, and we are stuck indoors for much longer during the frigid months.

There’s a key to rev up our immune system that can make a huge difference: you are what you eat. A healthy diet often prevents colds and flus or reduces their longevity. The antioxidants including vitamins C, A and E found in fruits and vegetables protect our cells and boost our immune system. Supplements can never replace the real thing.

A healthy diet year-round is crucial to keeping well. This means cutting down on inflammatory foods including white flour, white rice, sugar and saturated fats, as inflammation reduces your immune system. Stick to a balanced diet with lots of vegetables, fruits, herbs, spices, whole grains, healthy fats and lean protein.


Allicin, a natural chemical in garlic, fights common viruses. Add it to your cooked foods and salads. Don’t forget to have breath mints on hand!


Raw or lightly steamed broccoli contains vitamins A and C, as well as the compound sulforaphane, which helps ward off viruses. Add it to salads or use for dipping.

Vitamin C

For decades this has been the most popular vitamin for fending off viruses, but a handful of supplements won’t do much once you’re already infected. The best defence is to include a variety of fruits and vegetables daily with vitamin C to keep your immune system strong.

Oranges aren’t your only option — you can get more vitamin C from strawberries, kiwis, pineapple, mango, papaya, bell peppers, broccoli, cabbage, snow peas, brussels sprouts, cauliflower and kale.


Probiotics are beneficial bacteria that are good for the gut. We generally think of this as meaning digestion, but our gut health is actually a key component to many elements of our health, including 70 per cent of our immune system. Studies show that specific foods containing probiotics reduce the occurrence, length and severity of colds. These foods include sauerkraut, kefir, yogourts with live and active cultures, kimchi, kombucha and miso.

Chicken soup

There’s nothing like a warm bowl of chicken noodle soup when you’re under the weather, but does it actually help to fight off a cold? The combination of chicken, homemade broth, veggies (such as carrots, celery and onions) and noodles or rice is immune-boosting and soothing. The warm broth clears your nasal passages and keeps you hydrated. Mother was right!


We drink mug after mug of tea when we’re ill as it feels great on a sore throat, but it’s actually doing more to help, depending on the type. Black and green teas contain an amino acid called L-Theanine, which boosts our immune system. Black tea has more of this amino acid than green, but green tea protects the immune system against disease-causing free radicals. Drink up!


Spinach is rich in vitamin C and contains several antioxidants, which increases the ability for our immune system to fight infections. Eat it raw or cook it as little as possible to get the most nutrients.

Shellfish and fish

Indulging in fish or shellfish twice weekly may prevent colds and flus. Selenium, a mineral found in oysters, lobsters, crabs and clams, helps white blood cells produce proteins that fight flu viruses. Salmon, tuna, mackerel, and herring are loaded with omega-3 fats, which reduce inflammation.

Before you end up sidelined on the couch this winter, include a combination of these immune-boosting foods so you can have a healthy 2018.

By ROSE REISMAN    Special to the Star    Thu., Jan. 11, 2018
Rose Reisman is a nutritionist, caterer, speaker, media personality and author of 19 cookbooks. info@rosereisman.com

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The Microbiome: The Key to Optimal Health

Here’s how the microbiome—the colony go micro-organisms that lives on and in our bodies—might hold the key to a healthy immune system, mood and weight, and our overall well-being.

micro-organisms that lives on and in our bodies—
might hold the key to a healthy immune system, mood and weight, and our overall well-being.

Imagine that from the time you’re born, your body is hosting a daily house party. Who’s on the guest list? Roughly 40 trillion of your tiniest, closest friends. And like any lively party, there’s a mix of good and bad guests. This community of micro-organisms, which includes bac­teria, viruses, fungi and yeast, is collectively known as microbiota, or our microbiome. It’s often called the ‘forgotten organ’ and could be considered one of our largest in terms of cells. In fact, recent research suggests that we have around the same number of bacterial cells as human cells. During a natural birth, you’re first exposed to bacteria from your mother, and it’s estimated that your ecosystem is largely established by age three. We’re used to thinking of bugs as unwanted party crashers, but researchers are discovering that they play an important role in our overall well-being and may hold the key to a host of health-related issues.

If it seems like the word micro­biome just recently appeared on your radar, you’re not alone. It was only in 2008 that the National Institutes of Health Common Fund’s Human Microbiome Project was established to under­stand the microbiome and how it impacts the way our bodies function.

‘We knew that the microbiome was there, but we thought of it only as external and not really in our body. As research expands in this area, we’re discovering how much influence it has on well-being,’ says Kathy McCoy, the director of the Western Canadian Microbiome Centre and a professor at the Cumming School of Medicine in Calgary. ‘One thing we know for sure is that good bacteria benefit our health.’

Our gut houses the bulk of our bugs and can carry more than 1,000 different species. The hot spot is the large intestine, which is the most highly colonized by bacteria. ‘Bacteria help us digest foods we otherwise couldn’t, such as complex carbohydrates,’ says McCoy. ‘They increase our meta­bolic capacity, produce vitamins we can’t make ourselves and break down food so our bodies get needed nutrients.’

A healthy gut can determine which nutrients are absorbed and which toxins are blocked. ‘The state of our gut microbiota has drastically changed as we’ve transformed our diets, specifically due to a loss of fibre intake,’ says McCoy. ‘The consumption of more processed foods has negatively influenced the makeup of our microbiota.’

The key to a well-functioning microbiome is a diversity of good bacteria. The latest research shows how our micro­biome can affect our immunity, weight and mood, and reveals how you can nurture and strengthen your gut to improve your health.

‘Unlike genes or genetic disorders that are hardwired, we can manipulate our microbiome to some degree,’ says McCoy. By nurturing our gut to create a healthy microbiota, we equip it with better ammunition to fight potential invaders, such as bad bacteria (salmonella, for example), making it a strong ally for our immune system.

‘Over the past 50 years, in developing countries, the prevalence of autoimmune diseases, such as rheumatoid arthritis, Type 1 diabetes and celiac disease, has skyrocketed—and some, like Type 1 diabetes, are occurring at a younger age. At the same time, there’s a strong belief that the diversity in our microbiota has decreased,’ she says. By not supporting and nurturing our microbiome, we leave it less able to protect itself and more vulner­able to invaders. ‘The immune system in your gut needs to be equip­ped like an army, alert to recog­nize potential danger and armed to fight disease-causing microbes and pathogens,’ says McCoy.

Trying to shed a few pounds? Take a closer look at the health of your gut flora. ‘A study found that the micro­biota from obese people thrives on low-fibre, high-fat and high-sugar diets,’ says McCoy. Also, research suggests that certain bugs may make you desire specific foods, yet others can keep cravings in check. And multiple studies have demonstrated that if your microbiome is unbalanced, it can affect how efficiently food is metabolized.

There might be more to that ‘gut feeling’ we get. ‘There’s evidence that some bacteria residing in the gut can affect the brain and your emotional state,’ says McCoy. Researchers are working to unlock the gut-brain connection and believe that the micro­biome could hold the answer to a number of mental health conditions. ‘Researchers are finding that changes in the microbiota might be linked to gastrointestinal abnormalities, including anxiety, depr­es­sion, autism and hyperactivity. And there are also studies focusing on the pathway between the gut and several neurological disorders, such as Alzheimer’s disease and Parkinson’s disease,’ says McCoy.


1. Feed your microbiome 
One of the best—and easiest—ways to positively impact the gut is through diet. Start by increasing your fibre intake, found in grains, fruit and vegetables. Aim for 25 grams of fibre a day. Avoid high-fat and high-sugar diets, as they promote an unhealthy environment. Instead, eat foods that are full of variety, and include an abundance of fresh produce.

2. Fuel it with fermented foods
Populate the gut with good bacteria by filling up on foods with live and active cultures, such as kefir and some yogurts, and raw, unpasteurized fermented foods, such as kimchi, pickled vegetables and sauerkraut. Support digestive health and nourish the gut lining to more efficiently absorb nutrients by adding a scoop of a fermented yogurt protein powder to your morning smoothie.

3. Pop a probiotic 
‘Although our bodies have bacteria, environmental chemicals, poor nutrition, stress and medication easily affect their diversity. Choose a probiotic with 50 to 100 billion active bact­e­ria,’ says Toronto-based naturopathic doctor Sara Celik. We like a probiotic that’s jam-packed with 50 billion active cultures from 10 strains of bacteria, which is ideal for strengthening the immune system.

4. Monitor antibiotic use
Avoid the overuse of antibiotics, which can reduce the number of bacteria in your gut and break down its ability to resist infection from bad bacteria. ‘They’re drugs that don’t discriminate and kill all forms of bacteria—both good and bad—and can adversely alter the composition of your entire gut flora, which, we believe, is contributing to a host of chronic diseases,’ warns McCoy.

BY: GRACE TOBY         OCT 19, 2017 

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Lactic Acid Bacteria Can Protect Against Influenza A Virus

Lactic acid bacteria, commonly used as probiotics to improve digestive health, can offer protection against different subtypes of influenza A virus, resulting in reduced weight loss after virus infection and lower amounts of virus replication in the lungs, according to a study led by Georgia State University.

Influenza virus can cause severe respiratory disease in humans. Although vaccines for seasonal influenza viruses are readily available, influenza virus infections cause three to five million life-threatening illnesses and 250,000 to 500,000 deaths worldwide during epidemics. Pandemic outbreaks and air transmission can rapidly cause severe disease and claim many more human lives worldwide. This occurs because current vaccines are effective only when vaccine strains and circulating influenza viruses are well matched.

Influenza A virus, which infects humans, birds and pigs, has many different subtypes based on hemagglutinin (HA) and neuraminidase (NA) proteins on the surface of the virus. There are 18 different HA and 11 different NA subtype molecules identified, which indicates numerous HA and NA influenza virus combinations. As a result, it’s important to find ways to provide broad protection against influenza viruses, regardless of the virus strain.

Fermented vegetables and dairy products contain a variety of lactic acid bacteria, which have a number of health benefits in addition to being used as probiotics. Studies have found some lactic acid bacteria strains provide partial protection against bacterial infectious diseases, such as Streptococcus pneumoniae, as well as cold and influenza viruses.

This study investigated the antiviral protective effects of a heat-killed strain of lactic acid bacteria, Lactobacillus casei DK128 (DK128), a promising probiotic isolated from fermented vegetables, on influenza viruses.

Mice pretreated with DK128 intranasally and infected with influenza A virus showed a variety of immune responses that are correlated with protection against influenza virus, including an increase in the alveolar macrophage cells in the lungs and airways, early induction of virus specific antibodies and reduced levels of pro-inflammatory cytokines and innate immune cells. The mice also developed immunity against secondary influenza virus infection by other virus subtypes. The findings are published in the journal Scientific Reports.

“We found that pretreating the mice with heat-killed Lactobacillus casei DK128 bacteria made them resistant to lethal primary and secondary influenza A virus infection and protected them against weight loss and mortality,” said Dr. Sang-Moo Kang, lead author of the study and professor in the Institute for Biomedical Sciences at Georgia State. “Our results are highly significant because mice pretreated with DK128 had 100 percent survival and prevention of weight loss. This strain of lactic acid bacteria also equipped mice with cross-protective immunity against secondary lethal infection with influenza virus. Protection against influenza virus infection was not specific to a particular strain of influenza.

“Our study provides evidence that heat-killed lactic acid bacteria could potentially be administered via a nasal spray as a prophylactic drug against non-specific influenza virus infections.”

The researchers pretreated mice intranasally with heat-killed DK128 and then infected them with a lethal dose of influenza A virus, subtype H3N2 or H1N1. Mice pretreated with a low dose of DK128 showed 10 to 12 percent weight loss, but survived the lethal infection of H3N2 or H1N1 virus. In contrast, mice pretreated with a higher dose of heat-killed DK128 did not show weight loss. Control mice, which were not pretreated with DK128, showed severe weight loss by days eight and nine of the infection and all of these mice died.

Mice that received heat-killed lactic acid bacteria (DK128) prior to infection had about 18 times less influenza virus in their lungs compared to control mice.

Next, the researchers tested protection against secondary influenza virus infection by infecting pretreated mice with a different influenza A subtype from their primary virus infection. For the secondary virus infection, mice were exposed to H1N1 or rgH5N1.

The study’s results suggest that pretreatment with lactic acid bacteria, specifically DK128, equips mice with the capacity to have protective immunity against a broad range of primary and secondary influenza A virus infections.

Co-authors of the study include Drs. Yu-Jin Jung, Young-Tae Lee, Vu Le Ngo, Eun-Ju Ko and Ki-Hye Kim of the Institute for Biomedical Sciences at Georgia State; Drs. Young-Hee Cho, Sung-Moon Hong, Cheol-Hyun Kim of Dankook University; Drs. Ji-Hun Jang and Joon-Suk Oh of Tobico Inc.; Dr. Min-Kyung Park of Chungwoon University and Dr. Jun Sun of the University of Illinois at Chicago.

The study is funded by the National Institute of Allergy and Infectious Diseases and the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health and the United States Department of Defense.

Story Source:
Materials provided by Georgia State University. Note: Content may be edited for style and length.   December 13, 2017

Journal Reference:
Yu-Jin Jung, Young-Tae Lee, Vu Le Ngo, Young-Hee Cho, Eun-Ju Ko, Sung-Moon Hong, Ki-Hye Kim, Ji-Hun Jang, Joon-Suk Oh, Min-Kyung Park, Cheol-Hyun Kim, Jun Sun, Sang-Moo Kang. Heat-killed Lactobacillus casei confers broad protection against influenza A virus primary infection and develops heterosubtypic immunity against future secondary infection. Scientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-17487-8



Lack Of Sleep May Mess With Your Health On A Molecular Level

The impact goes far beyond grogginess and irritability. In many cases, sleep loss can give certain diseases the upper hand.

You no doubt have heard about the need to get a proper amount of sleep. Public health authorities continually declare we all need on average seven hours of slumber every night to be at our best. Yet while these recommendations come with a warning about the troubles stemming from a lack of sleep, when it comes to what happens inside our bodies, the details are usually few and far between.

Now, thanks to a team of Australian researchers, we have a clearer understanding of what happens at the molecular level when we disrupt these needed times of rest. The work reveals the impact goes far beyond grogginess and irritability. In many cases, sleep loss can give certain diseases the upper hand.

The team focused on the effects of what is known as the circadian rhythm. This biological phenomenon exists in all living organisms — even bacteria — and dictates when bodies should be active or at rest. The discovery was considered of such great importance the original researchers were awarded this year’s Nobel Prize in Medicine.

When the circadian rhythm was discovered, it was a mystery and any connection to health was speculative at best. But by 2007, researchers began to understand how disruptions in this rhythm can lead to health problems. A new branch of sleep medicine was developed in which disorders such as jet lag and altered timing of sleep became conditions worth documenting and treating based on our wake-sleep schedules.

Yet the studies did not stop there. Secondary consequences — known as sequelae — also were investigated and showed symptoms such as weight gain and poor decision making were directly linked to a lack of proper rest. As for the Australian researchers, they focused on a different problem with a much wider scope for health. Their interest lied in inflammation, one of the most troublesome issues in health today.

Body temperature, blood pressure, feeding times 

… are all affected.

The author’s investigations stems from a relatively recent finding from 2015. Researchers learned of a connection between our immunity and a small section of the brain known as the suprachiasmatic nucleus, more commonly known as the SCN. At just under two millimetres in length, you might think this region would have little effect on us. Yet close to 20 years of research has revealed this tiny region seated deep in the brain is the primary regulator of the circadian rhythm. As studies have shown, the area also impacts almost all of our bodily processes.

The extent of influence on our bodily functions by the SCN is fascinating. Body temperature, blood pressure, feeding times and (not surprisingly) the feelings of wakefulness and tiredness are all affected by this little region. The 2015 study shows the immune system also responds to the calls from this region, altering how it functions during the course of a day. During the day and into the early evening, our immunity is active. Late at night and into the early morning hours, it is at rest. The balance ensures the forces maintain a proper balance and do not end up hyperactive or fatigued.

With this in mind, the Australian researchers explored the consequences to immune balance as a result of sleep deprivation. They found studies both in animals and humans revealing even a slight change in our regular circadian rhythm can lead to the development of low-level inflammation. For the authors, the rise of inflammation could worsen chronic diseases such as allergies, asthma and chronic obstructive pulmonary disease. No to mention the inflammation also leads to a poorer response to infection.

Thanks to this overview, the Australian researchers have shown at the microscopic and molecular levels why getting those seven hours of sleep is so important. They underscore the necessity of making sure people take better care of their health when faced with disruptions to the sleep cycle as a result of shift work, time zone travel and other disturbances. Perhaps most importantly, for those who cannot change their sleep schedules, the inner struggles may require us to be more observant of our behaviours.

As to how to accomplish this balance, the authors suggested treatment options focusing on inflammation as a target. While this direction will no doubt take years to achieve, there may be more natural options to improve the outlook. Proper diet and exercise can help to minimize the extent of inflammation. In addition, the use of melatonin also can provide some assistance. Then there is the potential for probiotics. While still in the early stages, we may be able to one day find a mixture designed to help us stay balanced when the world around us is being disrupted.

11/06/2017    Jason Tetro Microbiology, Health & Hygiene Expert


Boost Bacteria to Bolster Your Brain

How can boosting bacteria in your body improve your brain health? Called the “second brain” by leading scientists, a healthy balance of flora in the gut helps to determine whether you’ll have a great memory and a strong resistance to brain disease.

And what happens in the gut plays a significant role in your brain health.  Restoring beneficial bacteria and some healthy yeasts in your intestines (yes, some yeasts are beneficial, just not the ones that cause yeast infections) can go a long way toward protecting your mental faculties and preventing brain diseases altogether.

Frequently when I tell people about this connection between intestinal and brain health—what is known as the gut-brain axis, they tell me that they are covered because they eat yogurt on a regular basis.  While yogurt may (or may not) help boost intestinal flora depending on whether it contains any live cultures at all, we need to give our guts a lot more than yogurt to help us establish a strong and healthy brain for life.

Let’s explore some of the exciting research into the link between beneficial microbes in our gut and our overall brain health.

Some probiotics actually function as antioxidants within the body, which can not only reduce the effects of free radical damage and aging, it is especially good news in the prevention and treatment of brain diseases.

That’s because the brain is vulnerable to free radical damage. Additionally, research at the University of California at Los Angeles (UCLA) found that consuming certain strains of probiotics could actually produce many brain health benefits, including improved sensory and emotional processing.

Since the brain plays a significant role in whether we suffer from mental health conditions like anxiety and depression, probiotics may also be helpful in addressing these serious health concerns. In animal studies conducted by the Department of Medicine at McMaster University, Hamilton, Ontario, Canada, and published in the medical journal Gastroenterology, the probiotic Bifidobacterium longum eliminated anxiety and normalized behavior.  It appeared to work by reducing the excitability of the nerves in the gut that connect through the vagus nerve to the central nervous system, and in doing so, eliminated anxiety.

Hungarian researchers found that intestinal inflammation is one of the key factors involved in depression and that treating the inflammation with probiotics (along with B complex vitamins, vitamin D, and omega 3 fatty acids) reduced depressive symptoms.

Additional French research demonstrates the power of boosting specific strains of probiotics to boost mood and psychological health.  They found that healthy study participants experienced reduced psychological stress, depression, anxiety, and anger and hostility, as well as improved problem-solving skills when taking the Lactobacillus helveticus and Bifidobacterium longum for 30 days.

While you can still enjoy yogurt if you are already doing so, please keep in mind that the above strains are not typically found in yogurt.  I’m not aware of any yogurt that contains the best brain-boosting strains.

Take a probiotic supplement containing proven strains of brain-boosting probiotics such as  Lactobacillus plantarum, Bifidobacterium longum, and Lactobacillus helveticus on a daily basis.  Store your probiotics in the refrigerator, and take them on an empty stomach. First thing in the morning with a large glass of water tends to work well for most people.

Additionally, kimchi—the national dish of Korea which is typically a fermented mixture of cabbage, chilis, and garlic—frequently contains a much more diverse group of beneficial microbes than yogurt, making it an excellent choice as a brain boosting food. Some types contain fish sauce so if you’re vegan be sure to choose a fish sauce-free option. It is delicious on sandwiches, over brown rice, or as a side-dish to many foods.  Be sure to choose kimchi that hasn’t been pasteurized to ensure the cultures are still intact.

By: Michelle Schoffro Cook           October 5, 2017
source: www.care2.com

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The Natural Dietary Add-On Found To Treat Depression

64% of depression and anxiety patients saw reductions in their symptoms.

Probiotics relieve the symptoms of depression, as well as helping with digestion problems, a new study finds.

The research was carried out on people with irritable bowel syndrome who were also depressed.

Twice as many reported improvements in depression symptoms if they took a specific probiotic.

Dr Premysl Bercik, senior study author, said:

“This study shows that consumption of a specific probiotic can improve both gut symptoms and psychological issues in IBS.
This opens new avenues not only for the treatment of patients with functional bowel disorders but also for patients with primary psychiatric diseases.”

The probiotic is called Bifidobacterium longum NCC3001.

Half of the 44 adults with IBS and mild to moderate anxiety or depression took a daily dose.
Over 10 weeks those taking the probiotic showed improvements in their IBS and depression and anxiety.

64% of those taking the probiotics showed psychological improvements compared with just 32% in the placebo group.

Brain scans revealed changes in multiple brain areas related to mood control.

Dr Bercik said:

“This is the result of a decade long journey — from identifying the probiotic, testing it in preclinical models and investigating the pathways through which the signals from the gut reach the brain.”

The study’s first author, Dr. Maria Pinto Sanchez, added:

“The results of this pilot study are very promising but they have to be confirmed in a future, larger scale trial.”

Other studies have also shown that probiotics have promise in treating depression.

One mouse study in which they were fed Lactobacillus, found that the probiotic reversed  their depression.

Another study found that a multispecies probiotic helped stop sadness from turning into depression.

Recent studies have repeatedly underlined the importance of diet for how we feel.

The new study was published in the journal Gastroenterology (Pinto-Sanchez et al., 2017).

source: PsyBlog